Mol
switch - An EU-funded Research and Development Project
A
Molecular Magnetic Switch that links the Biological and Silicon Worlds
(MOL SWITCH)
The
success of the Human Genome Sequencing Project means that DNA sequence
information is one of the greatest stores of information and is now of interest
to individuals. We will initiate work to construct a single-molecule DNA-sequencing
device, but closely linked to this development process, we
will also construct a nano-switch, based on a biological molecular motor
and a moving magnetic bead. This device will provide a link between the
biological world and the silicon-based microelectronics world. Such a device
is likely to find longer-term uses in the development of a wide range of
devices from biosensors to 'new generation' prosthetics and artificial limbs
constructed with controlling computer devices. In addition, the magnetic
bead attached to DNA can be used in the single-molecule DNA sequencing apparatus
(to overcome coiling due to entropy) and for monitoring the movement of
the DNA molecule.