Hosting MOL SWITCH

 
Nanonet

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Mol Switch
Project Aim
Project Description
Participant List
Innovation of Project
Annual Reports
EU policies
WorkPlan
1st WorkShop
Project Outcomes
News Releases


Mol Switch is supported
by funding from the
IST Programme of the
European Union


Mol Switch is part
of the
Future and Emerging
Technologies Scheme
What is Mol Switch


The NanoNet Virtual Network Site is pleased to be able to host the Web Pages for the EC Research and Development Project MOL SWITCH - A Molecular Magnetic Switch that links the Biological and Silicon Worlds.

This exciting EU-funded project started on 1st January 2003 and will run for three years and the total value of the award is €1,974,000. The Project has now completed and the Final Review stage will take place in May 2006.

The Project has made major progress and has allowed development of a nanoactuator that can provide the link between the biological and silicon worlds through a molecular switch.

There are six European Partners involved in the Consortium:
Project Coordinator

Dr John Gallop
Dr Patrick Josephs-Franks
Dr David Bensimon
ENS/CNRS
France
Prof Cees Dekker
TUDelft
The Netherlands
Prof Roberto Favilla
Dr Marie Weiserova
Institute of Microbiology
Prague Czech Republic
 

Publications arising from Mol Switch research:

Dessinges, M. N., T. Lionnet, X. G. Xi, D. Bensimon, and V. Croquette. 2004. Single-molecule assay reveals strand switching and enhanced processivity of UvrD. Proc Natl Acad Sci U S A 101:6439-44.

Pennadam, S. S., K. Firman, C. Alexander, and D. C. Górecki. 2004. Protein-polymer nano machines. Towards synthetic control of biological processes. Journal of Nanobiotechnology 2:1-7.

Saleh, O. A., C. Perals, F. X. Barre, and J. F. Allemand. 2004. Fast, DNA-sequence independent translocation by FtsK in a single-molecule experiment. European Molecular Biology Organisation Journal 23:2430-9.

Seidel, R., J. van Noort, C. van der Scheer, J. G. P. Bloom, N. H. Dekker, C. F. Dutta, A. Blundell, T. Robinson, K. Firman, and C. Dekker. 2004. Real-Time Observation of DNA Translocation by the Type I Restriction-Modification Enzyme EcoR124I. Nature Structural Molecular Biology 11:838 - 843.

van Noort, J., T. van der Heijden, C. F. Dutta, W. Lisle, K. Firman, and C. Dekker. 2004. Initiation of Translocation by Type I Restriction-Modification Enzymes is Associated with a Short DNA Extrusion. Nucleic Acids Research 32:6540-.47

Saleh, O.A., Bigot, S., Barre, F.X., and Allemand, J.F. (2005) Analysis of DNA supercoil induction by FtsK indicates translocation without groove-tracking. Nature Structral Molecular Biology 12: 436-440.

Seidel, R., Bloom, J.G.P., van Noort, J., Dutta, C.F., Dekker, N.H., Firman, K., Szczelkun, M.D., and Dekker, C. (2005) Dynamics of initiation, termination and reinitiation of DNA translocation by the motor protein EcoR124I. European Molecular Biology Organisation Journal 24: 4188-4197.
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