1. This proposal will contribute to the economic growth of the Community in the area of nanotechnology by the development of a nano-sensor, which is also a molecular switch that will provide a link between biological systems and silicon-based systems. These devices have the possibility of being tailored to specific requirements and, as such, are likely to create new markets and stimulate a dynamic and innovative industry within the EU.  Nanotechnology represents a major challenge to the EU since it is a cross-discipline research area at the very forefront of current technology and innovation. The assembled Consortium addresses all of these issues being both pan-European, pan-scientific discipline and includes leading researchers in this area.

2.    The main objective of this proposal is to produce a nano-actuator, based on a biological molecular motor that moves DNA, fuelled by ATP, which is able to detect the movement of biocompatible magnetic nano-particles attached to the DNA. This will allow the development on an integrated system that could be used for single-molecule DNA sequencing.

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3. On completion of the project, a prototype molecular magnetic switch will be produced.  The motive force of the device, together with its activity and stability in a range of environments will have been evaluated by a combination of techniques including the use of molecular tweezers as well as spectroscopic and optical methods.

4.   The baseline data against which the project will measure its progress will be by monitoring and comparing the development of devices based on less efficient motors.  A number of deliverables will be published in the public domain (as refereed scientific papers).  This will provide a public forum in which we can show progress.

5.    The success of the project will be based on (a) demonstration of the activity, efficiency and stability of the actuator, (b) its application to DNA sequencing, and (c) its commercial potential.  Published papers and Conference Proceedings will provide a more public measure of success.

6.    A project administrator will ensure the Consortium Members are aware of deadlines for project reports, meeting etc., and will co-ordinate the gathering of project assessment data.  A Steering Committee consisting of one member from each Consortium Group will oversee project progress and direction, and will prioritise work at all stages.